When a cell transcribes and translates genetic information, it generates a certain degree of randomness. This random fluctuation is called "noise". Noise in the genetic circuit can cause differences between cell function and phenotype, so it is getting more and more. s concern. But at present, little is known about the source of this noise and how it affects the function of cells.
The research results of John E. Ladbury and Stefan T. Arold of Texas State University indicate that cellular noise may come from the strong protein-protein interactions (PPi) and reveal this internal interaction. Eventually leads to the establishment of cell signaling pathways. Related academic achievements were published in the recent Cell sub-journal Trends in Biochemical and Science. The researchers say that protein multimerization or complex formation, changes in protein concentration, and integration of complex signals can all produce noise. The reason why noise can be detected is because the process of intracellular signal transduction is more inclined to a combination of a series of probabilistic events, rather than a linear propagation process.
The formation of cancer is related to the disorder of the cell signal network. Therefore, understanding the impact of this noise signal on the cell may have a newer understanding of cancer theory.
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