Such antibodies can target multiple components of the thyroid, represented by thyroglobulin and microsomes. Antibodies are mainly IgG, which can mediate ADCC activity and cause chronic lymphocytic thyroiditis, also known as Hashimoto thyroiditis. The detection method mostly uses immunofluorescence technology, with frozen sections of thyroid tissue as the substrate. You can also use RIA, ESISA and other methods to check. Strong positive reaction or high titer antibody is of diagnostic significance for Qiaoben thyroiditis and primary hypothyroidism, antibody changes are very important for the evaluation of disease treatment outcome, and differential diagnosis of Qiaoben thyroiditis and hyperthyroidism It also has greater value. Thyroid antibodies are rarely detected in the serum of normal people, or only 5% to 10% of people without disease symptoms have low-level reactions; the detection rate is higher in women and older people. The detection of this antibody may indicate that you have suffered from your own disease in the past, or it may be an early indicator of autoimmune disease.
There are thyroid stimulating antibodies (TSAb) in the serum of patients with hyperthyroidism (Graves disease), including long-acting thyroid stimulating hormone (LATS) and LATS (LATS-P). These antibodies act on the TSH receptors on the surface of thyroid cells, activating the receptors and promoting the release of thyroxine; too much thyroxine causes the body's hypermetabolism.
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