It’s nothing new to take a nap during a busy day, and a cup of caffeinated beverage will get us back to normal work. However, people with some sort of sleep disorder need to overcome their strong sleepiness even if they sleep for ten hours or even longer at night. For these people, caffeine doesn't work, and the more potent stimulant prescription is not much better. Now, a study of a small number of patients suggests that the disease may have a surprising cause: a naturally occurring compound that acts on the brain, in a sedative such as diazepam and Zanano. The key ingredients are very similar.
This disease is called "primary narcolepsy," which is different from the more familiar sleep-disordered sleepiness. Patients with sleep-disordered sleepiness tend to develop more sustained sleepiness during the day rather than “sleepiness raidsâ€. The cause of primary narcolepsy is unknown and the treatment plan is lacking. For a long time, neuroscientist David Rye of Emory University in Atlanta, USA, is deeply confused. “One third of our patients are disabled,†he said. “And they are all twenty or thirty.â€
Rye speculated that his sleepy patient's brain might contain some unknown compound. Rye and colleagues performed spinal puncture on 32 patients with excessive sleepiness and extracted brain fluid. Tests have shown that the patient's brain fluid has a hypnotic compound, a peptide, or a small protein, which may be produced by the brain, but its other characteristics are still unknown.
Based on the results of the study, Rye and colleagues studied seven patients who were taking a drug called flumazenil. The researchers said that after the patient was injected with flumazenil, several degrees of alertness were used. The measurement method showed that the patients all reached a near normal awake level. Rye said these effects can last up to several hours.
The researchers hope to get longer-term effects. They persuaded the pharmaceutical company that made the drug to donate a powder that can be made into a tablet under the tongue and can also be applied to the skin as a plaster. . The researchers reported in the paper that in the past four years, a 30-year-old patient has been using this combination and his condition has improved significantly. The patient's excessive sleepiness forced her to take a vacation, and now she is back to her own lawyer position.
To really make the results convincing, researchers need to repeat the study in larger, double-blind trials. Felicity, a neurologist at Northwestern University in Evanston, Ill., said that although repeated research is still needed, the study has opened a new window for us to reconsider how to treat excessive narcolepsy. .
Rye said that the next step is to find a more convenient way to discover the characteristics of this mysterious compound and conduct large-scale clinical trials to test the benefits of flumazenil.
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