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Tween is also called a Tween-type emulsifier, and is a condensate of a disc (sorbitol fatty acid ester) and ethylene oxide, and is a type of non-ionic detergent.
Chemical name: polyoxyethylene sorbitan fatty acid ester, referred to as polysorbate.
Because the company is the ester formed by sorbitol and different higher fatty acids, the Tween is actually the same type of products. In general fine chemical shops or chemical reagent companies, there are many kinds of 20, 40, 60, 80, depending on the Need to choose.
Tween-60 is stearate; Tween-80 is oleate; Tween-20 is lauric acid ester, polyoxyethylene sorbitan monolaurate and a part of polyoxyethylene sorbitan a mixture of laurates.
1, Tween 20
Alias: polyoxyethylene sorbitan fatty acid ester; Tween-20;
Properties: This product is a yellow or amber oily liquid with special odor and weak bitterness. The relative density is 1.01, the boiling point is 321 ° C, the flash point is 321 ° C, the refractive index is 1.472, and the viscosity (25 ° C) is 0.25 to 0.40 Pa/s. The molecule contains more hydrophilic groups, which are miscible with water, ethanol, methanol and ethyl acetate. They are insoluble in liquid paraffin, non-volatile oil and light petroleum. One part of this product is soluble in 130 cottonseed oil and 200. In a portion of toluene, the 5% aqueous solution has a pH of 5 to 7. The HLB value is 16.7.
Function and use: Polysorbate is a large class of nonionic surfactants with emulsification, diffusion, solubilization and stability. It is widely used as an emulsifier, dispersant, solubilizer, stabilizer, etc. in the pharmaceutical, daily chemical, food, textile and other industries. As a emulsifier, a high concentration of electrolyte and a change in pH have little effect on its emulsifying ability, and it is a large class of excellent oil/water emulsifiers. In the preparation of oil/water emulsifiers, they are often used in combination with sorbitan esters, and the stability of the emulsion is better. Change the type and amount of emulsifier used together to produce water/oil type or oil/water
2. Tween 80 is a hydrophilic surfactant that has a strong ruptured cell membrane and causes irritation, hemolytic and histamine release (sensitization). Tween 80 as a polymer itself has a very high purity fluctuation, high-purity Tween 80 is colorless and transparent, while most Tween products are yellow to brown, containing a lot of impurities or degradation products. The lipophilic ingredients in Tween 80 include unsaturated fatty acids, which are easily oxidatively degraded to produce more toxic components, and the resulting side effects will outweigh the benefits of the product itself. The medical community has confirmed that Tween 80 is used in injections and can cause allergic reactions, including shock, dyspnea, hypotension, angioedema, rubella and other allergic reactions. These adverse reactions can be very serious in human clinical trials. There are reports of death. Therefore, the use of Tween 80 is strictly limited, it is a potentially unsafe excipient, improper use can have a great impact on human health.
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